While Owen Farrell captains the team at fly-half ruaridh McConnochie has been called to start following two false starts.
A month the McConnochie was scheduled to start in a set of World Cup warm-up fittings against Wales, but pulled from both games due to injury.
The Bath winger will make his debut England face Italy in their at Newcastle, live on Sky Sports.
Farrell wears the No 10 jersey while Piers Francis begins at inside centre as George Ford chooses his place on the bench.
More to follow…
England: 15 Anthony Watson, 14 Ruaridh McConnochie, 13 Joe Marchant, 12 Piers Francis, 11 Jonny May, 10 Owen Farrell (c), 9 Ben Youngs, 1 Joe Marler, two Jamie George, 3 Dan Cole, 4 Joe Launchbury, 5 Courtney Lawes, 6 Tom Curry, 7 Mark Wilson, 8 Billy Vunipola.
Replacements: 16 Luke Cowan-Dickie, 17 Ellis Genge, 18 Kyle Sinckler, 19 Charlie Ewels, 20 Matt Kvesic, 21 Willi Heinz, 22 George Ford, 23 Joe Cokanasiga.

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