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The Republic of Irelands hopes of qualifying for Euro 2020 remainder on next months home match with Denmark after they lost in Switzerland.
Edimilson Fernandes and Haris Seferovic hit on the goals although victory would have booked the Irishs location.
Qualification will be secured by A win on the Danes on 18 November from Group D.
However, the Irish would be in conceding a second-half penalty superbly saved by Darren Randolph without captain Seamus Coleman, who had been sent off.
After Tuesdays game had been threatened by rain, Switzerlands first-half tempo yielded Fernandes hammered despite the attempts to keep the close-range shot of Shane Duffy at the next in the final seconds and Benfica striker Seferovic goal.
With the Republic changing in their early formation they created second-half strain but the held company to put themselves back on course for eligibility after their defeat in Copenhagen on Saturday.
The Republic still best Group D goal difference from Denmark with Switzerland a stage behind but equally the Danes and Swiss have games in hand, which come against sides Gibraltar and Georgia on 15 November.
Slips by the Swiss against Georgia and in their final game in Gibraltar – or Denmark – a Republic win against the Danes in their game will probably be sufficient to secure qualification for McCarthys side.
The Irish would need to win by two objects when the Swiss only select up four points in their last two games.
They might have the choice of a play-off place if this course fails.
McCarthy passed Brighton youngster Aaron Connolly a first start following his motivating cameo in Saturdays uninspiring lure in Georgia but rather it had been the Breel Embolo who was the most effective offender in the decisive first half of Borussia Monchengladbach.
With Embolo finding space easily, he helped the split out a series of first-half opportunities and Seferovics finish from.
Following the first half had been controlled by the Swiss the Republic rallied in the second phase but past having a Glenn Whelan shot blocked, had little to reveal in the way of opportunities that are clearcut.
Colemans dismissal came after he was adjudged to have handled an Embolo shot from the 76th minute, which followed his first-half yellow card to get the exchange with Arsenals Granit Xhaka.
While Fabian Schar also headed before Fernandes goal against the Republic woodwork from the second half, substitute Ricardo Rodriguezs spot-kick was beautifully saved by randolph.
The screen in Saturdays 0-0 draw in Georgia of the Republic came in for criticism and McCarthy chosen for the formation in addition to three changes.
Brighton youngster Connolly partnered James Collins in assault as Callum Robinson dropped out, with Preston midfielder Alan Browne taking more than Conor Hourihane.
Sheffield Uniteds Enda Stevens returned set up of Matt Doherty after suspension but was a part of a defence alongside John Egan and Shane Duffy as anticipated.
Despite Saturdays 1-0 defeat Denmark, Swiss boss Vladimir Petkovic opted to get an unchanged as the home side quickly took charge and his faith was rewarded.
The signs were ominous for its visitors as Xhaka tested Randolph at the seventh minute before Swiss player of this year Seferovic blasted reduced through the legs of Duffy to the net from just outside the box following Jeff Hendrick header.
In the opposite end, a Glenn Whelan corner was led by Duffy right in keeper Yann Sommer before the break but it was a Republic target effort that was rare.
McCarthy introduced Callum ODowda for striker Collins in half-time after abandoning his three at the formation midway through the first half plus it helped the people create some pressure in the third quarter.
But the Swiss continued to carve with Randolph needing to tip within a Seferovic header then visiting the header of Schar.
Connolly was replaced by Scott Hogan about 70 minutes before Colemans dismissal when conceding the penalty because he picked up another yellow card.
The heroic Randolph extended to keep out Rodriguezs spot-kick but can do nothing like Fernandes blasted in from close range in the final minute of injury-time despite Duffys attempts.
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